Morpholine News Bromoform


Bromoform structural formula

Structural formula

Business number 01JA
Molecular formula CHBr3
Molecular weight 252.73


Methyl tribromide,



Aliphatic halogenated derivatives

Numbering system

CAS number:75-25-2

MDL number:MFCD00000128

EINECS number:200-854-6

RTECS number:PB5600000

BRN number:1731048

PubChem number:24863014

Physical property data

1. Properties: Colorless heavy liquid with a chloroform-like smell. [1]

2. Melting point (ºC): 6~9[2]

3. Boiling point (ºC) : 149.5[3]

4. Relative density (water = 1): 2.89[4]

5. Relative Vapor density (air=1): 8.7[5]

6. Saturated vapor pressure (kPa): 0.75 (25ºC)[6]

7. Critical pressure (MPa): 6.09[7]

8. Octanol/water partition coefficient: 2.38[8]

9. Solubility: Slightly soluble in water, soluble in ethanol, ether, chloroform, benzene, etc. [9]

10. Specific heat capacity (KJ/(kg·K), 18~50ºC, constant pressure): 0.519

11. Electrical conductivity ( S/m, 25ºC): <2×10-8

12. Vapor pressure (kPa, 22ºC): 0.67

13. Vapor pressure ( kPa, 48ºC): 2.67

14. Volume expansion coefficient (K-1): 0.00091

15. Refractive index at room temperature (n20 ): 1.5976

16. Refractive index at room temperature (n25): 1.5956

17. Lennard-Jones parameter (A): 8.153

18. Lennard-Jones parameter (K): 162.2

19. Solubility parameter (J·cm-3)0.5 sup>: 21.726

20. van der Waals area (cm2·mol-1): 6.810×109

21. van der Waals volume (cm3·mol-1): 49.980

22. Gas phase standard entropy (J·mol-1·K-1): 330.70

23. Gas phase standard hot melt (J·mol-1·K-1): 70.98

24. Liquid phase standard hot melt (J·mol-1·K– 1): 129.9

Toxicological data

1. Acute toxicity[10]

LD50: 933mg/kg (rat oral); 414mg/kg (rat intraperitoneal ); 1072mg/kg (orally administered to mice)

LC50: 12100mg/m3 (inhaled to mice, 2h)

2. Irritation No data available

3. Subacute and chronic toxicity [11] Rat inhalation 0.25mg/L, 4 hours a day , 2 months later, abnormal liver and kidney function.

4. Mutagenicity [12] Microbial mutagenicity: Salmonella typhimurium 50μl/dish. Sister chromatid exchange: human lymphocytes 80 μmol/L. DNA damage: human lung 100 μmol/L (3h).

5. Teratogenicity[13] Mice were orally administered the lowest toxic dose (TDLo) 200mg/kg for many generations, causing hepatobiliary and Developmental malformations of the genitourinary system.

6. Carcinogenicity[14] IARC Carcinogenicity Comment: G3, insufficient evidence of carcinogenicity to humans and animals.

Ecological data

1. Ecotoxicity[15] LC50: 40.4mg/L (48h) (medaka)

2. Biology Degradability[16]

Aerobic biodegradation (h): 672~4320

Anaerobic biodegradation (h): 2688 ~17280

3. Non-biodegradability[17]

Photooxidation half-life in air (h): 1299~ 12989

First-order hydrolysis half-life (h): 6.02×106

4. Bioaccumulation [18] BCF: 7.1~21 (carp, exposure concentration 100mg/L, exposure time 6 weeks); 7.7~19 (carp, exposure concentration 10mg/L, exposure time 6 weeks)

5. Other harmful effects[19] It decomposes when exposed to alkali, but it is a highly persistent compound in water and will not be biodegraded. Especially if it stays in drinking water for a long time, it will cause harm.

Molecular structure data

1. Molar refractive index: 29.83

2. Molar volume (cm3/mol): 84.9

3. Isotonic specific volume (90.2K ): 225.7

4. Surface tension (dyne/cm): 49.8

5. Polarizability (10-24cm3): 11.82

Compute chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): 2.8

2. Number of hydrogen bond donors: 0

3. Number of hydrogen bond acceptors: 0

4. Number of rotatable chemical bonds: 0

5. Number of tautomers: none

6. Topological molecule polar surface area 0

7. Number of heavy atoms: 4

8. Surface charge: 0

9. Complexity: 8

10. Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 1

Properties and stability

1. Stability[20] Stable

2. Incompatible substances[21] Strong oxidants, active metal powders

3. Conditions to avoid contact[22] Light

4.Polymerization hazard[23] No polymerization

5. Diversity products[24] Bromine Hydrogen

Storage method

Storage Precautions[25] Store in a cool, ventilated warehouse. Keep away from fire and heat sources. The storage temperature does not exceed 32°C and the relative humidity does not exceed 80%. Keep container tightly sealed. They should be stored separately from oxidants, active metal powders, and food chemicals, and avoid mixed storage. The storage area should be equipped with emergency release equipment and suitable containment materials.

Synthesis method

1. Under alkaline conditions, acetone reacts with sodium hypobromite to obtain tribromoacetone, which will continue to decompose under alkaline conditions to obtain crude product. After distillation, washing, filtering and drying, the finished product is obtained.


1. It can be used as dye intermediates, disinfectants, analgesics, anesthetics, refrigerants, mineral processing agents, precipitants, solvents and anti-explosion liquid components.

2. Used as solvent, refractive index liquid and specific gravity liquid.

3. Used as solvent and organic synthesis intermediate. [26]


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