3-[[3-[(Dimethylamino)carbonyl]-2-hydroxyphenyl]amino]-4-[[(R)-1-(5-methylfuran-2-yl)propyl]amino Preparation method of ]-3-cyclobutene-1,2-dione_Kain Industrial Additive

Background and overview[1] 3-[[3-[(Dimethylamino)carbonyl]-2-hydroxyphenyl]amino]-4-[[(R)-1-(5-methylfuran-2-yl)propan [Hydroxy]amino]-3-cyclobutene-1,2-dione, also known as 2-hydroxy-N,N-dimethyl-3-[[2-[[1(R)-[5-methyl -4-(1-methylethyl)-2-furyl]propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]-benzamide, is a type of 1,2-substituted 3,4-dioxo-1-cyclobutene compounds. It is a potent allosteric antagonist of CXCR1 and CXCR2 and is for scientific use only. Preparation[1] 2-Hydroxy-N,N-dimethyl-3-[[2-[[1(R)-(5-methyl-2-furyl)propyl]amino]-3,4-di Preparation of oxy-1-cyclobuten-1-yl]amino]benzamide monohydrate (Type 4): To a suspension of 10.1 g (2D1) (1.06 equivalents) in 30 ml water and 40 ml 2-methyltetrahydrofuran, add 6.5 ml 32% sodium hydroxide solution. Test…

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