Preparation of (1R,2R)-1,2-diphenylethylenediamine_Kain Industrial Additive
Background and overview[1][2] Optically active (1S, 2S)-(-)-1,2-diphenylethylenediamine; (1R,2R)-1,2-diphenylethylenediamine is an important chirality Reagents have been widely used in asymmetric synthesis and optical resolution, such as asymmetric hydroxylation reactions of alkenes, asymmetric aldol condensation reactions, asymmetric Diels-Alder reactions, asymmetric allylation reactions of carbonyl groups, optical activity The synthesis of allenyl alcohol and propynyl alcohol, the asymmetric epoxidation reaction of alkenes without functional groups, and the resolution of…
Preparation of (1R,2R)-(+)-1,2-diaminocyclohexane-N,N’-bis(2-phenylphosphine-1-naphthoyl)_Kain Industrial Additive
Background and overview[1] (1R,2R)-(+)-1,2-diaminocyclohexane-N,N’-bis(2-phenylphosphine-1-naphthoyl) is an organic phosphine ligand commonly used in transition metal catalyzed reactions. This chiral coordination has proven to be very successful in the amination of butadiene monoepoxides, a type of epoxide and a potential prospect for asymmetric synthesis starting materials (or substrates). Preparation[1] Add 1.90g (5.33mmol) 2-diphenylphosphine-1-naphthoic acid and 42ml dichloromethane into a 100ml round-bottomed flask. After cooling to 0°C, add 1.78g…
