Preparation of (2-butyl-5-nitro-3-benzofuranyl)[4-[3-(dibutylamino)propoxy]phenyl]methanone_Kain Industrial Additive
Background and overview[1] Synthesis of (2-butyl-5-nitro-3-benzofuryl)[4-[3-(dibutylamino)propoxy]phenyl]methanone as dronedarone hydrochloride intermediate. Dronedarone hydrochloride, chemical name: N-(2-butyl-3-(4-(3-dibutylaminopropoxy)benzoyl)benzofuran-5-yl)methanesulfonamide hydrochloride Salt is an antiarrhythmic drug. Preparation[1] The preparation of (2-butyl-5-nitro-3-benzofuryl)[4-[3-(dibutylamino)propoxy]phenyl]methanone is as follows: The specific steps are as follows: at room temperature, put in butanone (240L), potassium carbonate (17.9kg), 2-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran (40.0kg) ) and N-(3-chloropropyl)dibutylamine (26.6kg) into the reaction kettle, stir and heat to 75~81°C, keep the reaction for 9 hours,…
Preparation method of (2-chlorophenyl)methylsulfonyl chloride_Kain Industrial Additive
Background and overview[1] Acid chlorides including (2-chlorophenyl)methylsulfonyl chloride are a very important class of compounds, widely used as intermediates and raw materials in organic and pharmaceutical synthesis, and are an important source of sulfonyl groups. Due to the important role and widespread use of sulfonyl chloride, a variety of preparation methods for sulfonyl chloride have been developed. Structure Preparation method[1] Generally speaking, alkylsulfonyl chlorides can be…
Application of 2,4-dichlorophenylhydrazine_Kain Industrial Additive
Background and overview[1] 2,4-Dichlorophenylhydrazine is an important chemical raw material. The current preparation methods of 2,4-dichlorophenylhydrazine cannot avoid operations such as diazotization, sulfonation, and reduction of 2,4-dichloroaniline. These operations have high requirements on reaction temperature, and diazotization must be Low-temperature reaction, and poor control of the dripping speed and reaction degree of the sodium nitrite solution will lead to the formation of by-products and will also…
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Application of 6-hydroxyanthranilic acid_Kain Industrial Additive
Background and overview[1] 6-Hydroxyanthranilic acid is a carboxylic acid derivative and can be used as a pharmaceutical synthesis intermediate. If 6-hydroxyanthranilic acid is inhaled, please move the patient to fresh air; if skin contact occurs, take off contaminated clothing, rinse the skin thoroughly with soap and water, and seek medical attention if you feel unwell; if contact with eyes , you should separate your eyelids, rinse…
Preparation method of 4-n-heptylbenzoyl chloride_Kain Industrial Additive
Background and overview[1] 4-n-Heptylbenzoyl chloride can be used as a pharmaceutical synthesis intermediate. If 4-n-heptylbenzoyl chloride is inhaled, move the patient to fresh air; if the skin comes into contact, take off contaminated clothing, rinse the skin thoroughly with soap and water, and seek medical treatment if you feel uncomfortable; if the eyes are clear In case of contact, separate eyelids, rinse with running water or…
Application of 4-(4-methylpiperazinemethyl)benzoyl chloride dihydrochloride_Kain Industrial Additive
Background and overview[1] 4-(4-Methylpiperazinemethyl)benzoyl chloride dihydrochloride can be used as a pharmaceutical synthesis intermediate. If 4-(4-methylpiperazinemethyl)benzoyl chloride dihydrochloride is inhaled, move the patient to fresh air; if skin contact occurs, remove contaminated clothing and wash skin thoroughly with soap and water. , if you feel discomfort, seek medical attention; if the eye contact occurs, separate the eyelids, rinse with running water or saline, and seek medical…
Preparation method of 1-phenyl-2,2,2-trifluoroethylamine_Kain Industrial Additive
Background and overview[1] 1-Phenyl-2,2,2-trifluoroethylamine can be used as a pharmaceutical synthesis intermediate. Preparation[1] The preparation of 1-phenyl-2,2,2-trifluoroethylamine is as follows: Synthesis of compound 4-b: Dissolve 4-a (1.00g, 5.74mmol, 781.25uL, 1.00eq) in EtOH (8.00mL) and water (4.00mL) at 25°C, then add hydroxylamine hydrochloride (598.31mg, 8.61mmol, 1.50 eq) and sodium acetate (941.70 mg, 11.48 mmol, 2.00 eq). The resulting mixture was stirred at 80°C for 15 hours. The…
1-Preparation method of o-chlorophenylethylamine_Kain Industrial Additive
Background and overview[1] 1-O-chlorophenylethylamine can be used as a pharmaceutical synthesis intermediate. If 1-o-chlorophenylethylamine is inhaled, please move the patient to fresh air; if there is skin contact, take off contaminated clothing, rinse the skin thoroughly with soap and water, and seek medical treatment if you feel uncomfortable; if there is eye contact , you should separate your eyelids, rinse with running water or saline, and…
Preparation method of sodium 2,4,6-trichlorophenol_Kain Industrial Additive
Background and overview[1-2] The composition of high-boiling chlorophenols is very complex, mainly containing o-chlorophenol, 2,4-dichlorophenol, 2,4,6-trichlorophenol, 4-bromo-2,5-dichlorophenol, 4 , 4-dichlorodiphenylsulfone and dichlorophenoxychlorophenol, etc. Among them, chemical products with relatively high added value are o-chlorophenol, 2,4-dichlorophenol and 2,4,6-trichlorophenol. The content of 2,4,6-trichlorophenol is the largest among high-boiling chlorophenols, at about 55 wt%, while the content of 2,4-dichlorophenol is second, at about 15 wt%. 2,4,6-Trichlorophenol is an important…
Application of 2,4,6-Trichlorobenzaldehyde_Kain Industrial Additive
Background and overview[1] 2,4,6-Trichlorobenzaldehyde can be used as a pharmaceutical synthesis intermediate. Preparation[1] The preparation of 2,4,6-trichlorobenzaldehyde is as follows: The specific steps are as follows: Under argon protection and minus 78 degrees Celsius, add 10.0g (55.1mmol) 1,3,5-trichlorobenzene and 100ml ultra-dry tetrahydrofuran into a 250ml single-neck flask. Then add 23ml (2.4M, 55.2mmol) n-butyllithium n-hexane solution dropwise, and stir for 30 minutes at minus 78 degrees Celsius.…
