1′-biphenyl Preparation method of -4-formate ester_Kain Industrial Additive

Background and overview[1] Prostaglandins are an important class of endogenous physiologically active substances. They are important mediators in various physiological processes and have high pharmacological activity. Clinically, prostaglandins are all artificially synthesized. Coreylactonephenylbenzoate, (3aR, 4S, 5R, 6aS)-(-)-hexahydro-4-(hydroxymethyl)-2-oxo-2H-cyclopenta[ b] Furan-5-yl 1,1′-biphenyl-4-carboxylate) is a chiral intermediate for the synthesis of PGF2α prostaglandin drugs. Its molecular formula is C21H20O5 and its chemical name is hexahydro-4-(hydroxymethyl). -2-Oxo-2H-cyclopenta[b]furan-5-yl 1,1′-biphenyl-4-carboxylate, usually including…