Application of 6-fluoro-3-piperidin-4-yl-1,2-benzisoxazole hydrochloride_Kain Industrial Additive

Background and Overview[1][2] 6-Fluoro-3-piperidin-4-yl-1,2-benzisoxazole hydrochloride is an intermediate for the preparation of paliperidone. Paliperidone is the main active metabolite of the anti-tension agent risperidone (Risperdone); risperidone metabolized in the liver is mainly hydroxylated into 9-hydroxyrisperidone or paliperidone through the cytochrome (CYP) P4502D6 pathway. Risperidone. Paliperidone has pharmacological properties and potency comparable to the parent drug risperidone, but has a longer elimination half-life. Paliperidone differs from risperidone…

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