Preparation and application of 1-(4-methoxyphenyl)-1,2,2-tristyrene_Kain Industrial Additive
Background and overview[1] After hydrolysis of 1-(4-methoxyphenyl)-1,2,2-tristyrene, the intermediate 1-(4-hydroxyphenyl)-1,2,2-tristyrene can be prepared. The intermediate can be used to synthesize tetrastyrene Schiff base red light zinc ion probe to effectively detect atypical metal ions. Preparation[1] Dissolve diphenylmethane (12mmol, 2.02g) in 50ml tetrahydrofuran, at minus 20°C, under nitrogen protection, add dropwise 2.5M n-butyllithium (10mmol, 4ml), and then add dropwise 4-methoxybis Benzophenone (12mmol, 3.03g) was heated to room…
2,4-Dimethyl-6-tert-butylphenol_Kain Industrial Additive
[Background and Overview][1][2] 2,4-Dimethyl-6-tert-butylphenol, Chinese alias antioxidant 6BX; 2-tert-butyl-4,6-dimethylphenol; antioxidant LA; antioxidant Topanol- A; CAS1879-09-0, molecular formula C12H18O, molecular weight 178.27100. 2,4-Dimethyl-6-tert-butylphenol is an energy The substance that quickly reacts with free radicals to terminate the chain reaction is a new type of high-temperature resistant aviation fuel antioxidant. Acrylic inhibitor, also often called a stabilizer, is an intermediate for a variety of polymer antioxidants and is…
Synthesis method of 1,2,4-trimethylbenzene and its application examples_Kain Industrial Additive
Background and overview[1][2][3][4] 1,2,4-Trityl is a homologue of benzene, also called trimethylene or pseudocumene. It is mainly used in analytical reagents, organic synthesis and pharmaceutical industry. 1,2,4-trimethylbenzene has stable chemical properties. It is an important fine chemical raw material with high quality and high added value. It can be used to synthesize resins, dyes, medicines, plasticizers, etc. It is an ideal solvent for the production of…
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cis-Methanesulfonic acid-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolane- Preparation of 4-yl]methyl ester_Kain Industrial Additive
Background and overview[1] At present, anti-infective drugs have become the third largest class of drugs in the world after cardiovascular system drugs and central nervous system drugs, occupying an important share in the world market. Itraconazole, as a representative variety of anti-infective drugs, has become the best-selling variety in the world in 2006. With its unique mode of action and excellent efficacy, its market share is…
Detection method of 1,2,4,5-Tetrachlorobenzene_Kain Industrial Additive
Background and overview[1] 1,2,4,5-Tetrachlorobenzene is soluble in alcohol, ether, benzene, chloroform and carbon disulfide, but insoluble in water. Used to make pesticides, fire retardants and other organic synthetic products. Preparation[1] Method 1: Method 2: Direct chlorination of benzene or chlorobenzene at high temperature under the catalysis of copper or iron; Method 3: Detection method[2] Ultrasound-assisted dispersive liquid-liquid microextraction-gas chromatography for detection of chlorobenzene in sludge: Chlorobenzene…
Preparation method of 1-phenyl-2,2,2-trifluoroethylamine_Kain Industrial Additive
Background and overview[1] 1-Phenyl-2,2,2-trifluoroethylamine can be used as a pharmaceutical synthesis intermediate. Preparation[1] The preparation of 1-phenyl-2,2,2-trifluoroethylamine is as follows: Synthesis of compound 4-b: Dissolve 4-a (1.00g, 5.74mmol, 781.25uL, 1.00eq) in EtOH (8.00mL) and water (4.00mL) at 25°C, then add hydroxylamine hydrochloride (598.31mg, 8.61mmol, 1.50 eq) and sodium acetate (941.70 mg, 11.48 mmol, 2.00 eq). The resulting mixture was stirred at 80°C for 15 hours. The…
Preparation method of 2,2,2-triphenylacetophenone_Kain Industrial Additive
Background and overview[1] 2,2,2-Triphenylacetophenone can be used as a pharmaceutical synthesis intermediate. If 2,2,2-triphenylacetophenone is inhaled, move the patient to fresh air; if skin contact occurs, take off contaminated clothing, rinse the skin thoroughly with soap and water, and seek medical attention if you feel unwell. ; If eye contact occurs, separate eyelids, rinse with running water or saline, and seek medical attention immediately; if ingested,…
N-[5-[4-[(1,1-dioxo-4-thiomorpholinyl)methyl]phenyl][1,2,4]triazolo[1,5-A]pyridine -2-yl]cyclopropanecarboxamide_Kain Industrial Additive
Background and overview[1] N-[5-[4-[(1,1-dioxo-4-thiomorpholinyl)methyl]phenyl][1,2,4]triazolo[1,5- A]pyridin-2-yl]cyclopropanecarboxamide can be used as a pharmaceutical synthesis intermediate. Preparation[1] N-[5-[4-[(1,1-dioxo-4-thiomorpholinyl)methyl]phenyl][1,2,4]triazolo[1,5- Preparation of A]pyridin-2-yl]cyclopropanecarboxamide (8A): 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborane- 2-yl)-benzyl)thiomorpholine 1,1-dioxide (Intermediate 1A) (20.18g, 53mmol), N-(5-bromo-[1,2,4]triazolo[1 ,5-a]pyridin-2-yl)cyclopropanecarboxamide (Intermediate 7A) (16.45g, 59mmol), Pd(dppf)Cl2 (3.91g, 5mmol), K2CO3 (22.06g, 160mmol) were added to 250mL in sequence into a three-necked flask, then add 1,4-dioxane (100 mL) and water (25 mL), and raise the temperature to 90°C under argon protection…
Preparation method of 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride_Kain Industrial Additive
Background and overview[1] 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride can be used as a pharmaceutical synthesis intermediate. Preparation[1] 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride is prepared as follows: 1) Mix 2,3,5-trimethylphenol (50.03g, 0.367 mol), isoprene (25.09g, 0.368 mol) and molten zinc chloride (5.94g, 0.044 mol) with anhydrous Acetic acid (47ml) was stirred at room temperature for 14 hours. The cloudy red mixture is then gradually heated and becomes clear. After refluxing, the reaction mixture…
2,5-Dimethylbenzaldehyde-DNPH_Kain Industrial Additive
Background and overview[1] The 2,4-dinitrophenylhydrazine (DNPH) colorimetric method is a classic method for determining the carbonyl content of proteins. The oxidized protein carbonyl content increases, and the carbonyl group can react with 2,4-dinitrophenylhydrazine to form 2,4-dinitrophenylhydrazone, 2,4-dinitrophenylhydrazone is a reddish-brown precipitate. After dissolving the precipitate with guanidine hydrochloride, the absorbance value at 370nm can be read on a spectrophotometer to determine the protein. The carbonyl content.…
