(2S-cis)-(+)-2

Background and overview[1] (2S-cis)-(+)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepine-4(5H) -Ketone is a key intermediate in the synthesis of diltiazem. The current route to synthesize diltiazem is mainly to first synthesize (2S-cis)-(+)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepine Zo-4(5H)-one is then obtained through a two-step reaction of N-alkylation and O-acetylation. The chemical name of diltiazem is cis-(+)-5-[(2-dimethylamino)ethyl]-2-(4-methoxyphenyl)-3-acetoxy-2,3- Dihydro-1,5-benzothiazepine-4-(5H)-one hydrochloride is a selective calcium channel blocker. Diltiazem is a benzodiazepine calcium antagonist. It was originally developed by the Japanese…